NOTUM inhibition increases endocortical bone formation and bone strength
نویسندگان
چکیده
منابع مشابه
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength of Intact Bones in Adult Male Rats
We investigated the systemic effect of sclerostin monoclonal antibody (Scl-Ab) treatment on intact non-operated bones in an open osteotomy male Sprague Dawley (SD) rat model. Six-month-old male SD rats were subjected to transverse osteotomy at the right femur mid-shaft. Rats were injected subcutaneously with vehicle or Scl-Ab (25 mg/kg, 2 times per week) treatment for 9 weeks. Compared with veh...
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ژورنال
عنوان ژورنال: Bone Research
سال: 2019
ISSN: 2095-6231
DOI: 10.1038/s41413-018-0038-3